ISO 21748:2017 assumes that recognized, non-negligible systematic effects are corrected, either by applying a numerical correction as part of the method of measurement, or by investigation and removal of the cause of the effect.
The analytical method was validated according to English and Polish versions of European standards (PN-ISO 3534-1 2009; PN-ISO 3534-2 2010; PN-ISO 5725-1-6 2002; ISO/TS 21748 2004; PN-EN ISO/IEC 17025 2005), internal test procedures, and standard protocols (IB03 research procedure, the research methods validation; IB05 research procedure, the estimation of measurement uncertainty). It was not validated for robustness, carryover, dilution integrity, or mass spectrometer parameter changes (e.g., ion source and quadruple temperatures, ionization voltage). Validation studies included sensitivity measured by the limit of detection (LOD) and limit of quantitation (LOQ), working range, linearity and calibration model fits (correlation), precision (repeatability expressed by standard deviation and relatively standard deviation), accuracy (recovery pattern, certificated value of CRM), coefficient of variation, and uncertainty. All calculations were performed using the ChemStation software Excel 2007 and online available authorized computer program e-Stat.
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